Hence, early TNFR1-inducible NFκB activation associated with reduced hepatocellular death seems to be linked to an inhibition of compensatory hepatocyte proliferation in Mdr2−/− mice, indicated by a reduced expression of proliferation and tumour markers [117], while at later time points NFκB mediates survival of transformed hepatocytes that is responsible for the progression to HCC [125]. Here, TNFRSF1A is linked to hepatocellular carcinoma.