FDXR and neoplasm: Histological analysis showed that like Trp53+/− (23 out of 24) and Fdxr+/− (26 out of 29) mice, Fdxr+/−; Trp53+/− mice (24 out of 25) were tumor-prone as compared with WT mice (6 out of 27) (p < 0.0001 by Fisher’s exact test) (Fig. 3B, Supplementary Fig. S4 and Supplementary Tables S1–S4).