Higher NPY1R gene expression in ER+ BC patients regardless of HER2 status predicted longer RFS [HR = 0.8 (range: 0.68–0.94, logrank P = 0.0072)] (Fig. 6A) and OS [HR = 0.62 (range: 0.43–0.89, logrank P = 0.009)] (Fig. 6B). The gene discussed is ESR1; the disease is breast cancer.