TFG and hereditary motor and sensory neuropathy, Okinawa type: While previous reports highlighted the toxic effects of the mutant TFG as causes of the pathogenesis of HMSN-P10,14,15, our findings that at least some of the motor symptoms observed in HMSN-P were recapitulated in vMNTFG KO (i.e., muscle atrophy, muscle weakness) raise the possibility that the pathogenesis of HMSN-P might involve both the loss of functional TFG and direct toxic effects of the mutant TFG, rather than necessarily being attributable entirely to the latter.