In the metabolic syndrome sub-network, five genes had high degrees of connection and could be considered hub genes: PTPRD, DCC Netrin 1 Receptor (DCC), Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6), Unc-13 Homolog C (UNC13C), and Contactin 4 (CNTN4). The gene discussed is PTPRD; the disease is metabolic syndrome.