PDLIM2 was negatively correlated with the TMB in BLCA, cholangiocarcinoma, COAD, LIHC, LUAD, LUSC, paraganglioma, prostate adenocarcinoma, pulmonary enteric adenocarcinoma, stomach adenocarcinoma, and thymoma and positively correlated with ACC (Fig. 7a). The gene discussed is PDLIM2; the disease is paraganglioma.