TP53 and mesothelioma: We observed that shRNA knockdown of ROCK1 inhibited TEAD reporter activity in NF2 mutant mesothelioma H2373 cells (Fig. 4a) and NF2 and p53 DNA contact mutant MDA-MB-231 cells (Fig. 4b), whereas ROCK2 knockdown lacked these effects (Fig. 4a, b and Supplementary Fig. 12a) As controls, expression levels of ROCK1 and ROCK2 were similar in each of these cells (Supplementary Fig. 12b).