CXCL8 and neoplasm: Indeed, CRC pseudolumina frequently stained positive for both IL-8 and CD66b (Fig. 4D), and Fisher’s exact test showed a significant association between IL-8 and CD66b positivity (p = 0.0014, n = 35), as defined by the presence of at least 20 positive pseudolumina/cm2 tumour area.