LGALS1 and neoplasm: LGALS1 encodes the secretory protein Gal1, which is confirmed to promote tumor progression through a variety of mechanisms, such as angiogenesis,54 epithelial-mesenchymal transformation,24 and immunosuppression.19 23 In 1995, Perillo et al17 first reported that Gal1 induced apoptosis of activated human T cells in vitro.