The chemokines CCL2, CCL3, CCl4, CCL5, CXCL9, CXCL10, and CXCL11 are known to be associated with T cell related tumor infiltration.37 CXCL9, CXCL10, and CXCL11 (ligands of CXCR3) are particularly critical because their expression is associated with prolonged disease-free survival in cancer patients.6 To explore the intricate mechanism of CD8+ T cell regulation by KDM4C inhibition, we performed RNA-seq and found that the cytokine–cytokine receptor signaling pathway was significantly enriched after SD70 treatment and that the expression of many chemokines was significantly upregulated. This evidence concerns the gene KDM4C and cancer.