CD8+ T cells are the main cytotoxic immune cells in tumors and have the abilities to promote antitumor immunity and induce tumor cell death by secreting cytotoxic molecules, such as IFN-γ, GZMB, Perforin, and CD107a.24 To clarify the effect of KDM4C on CD8+ T cells, we analyzed the expression levels of cytotoxicity markers (IFN-γ, GZMB, Perforin, and CD107a) on tumor-infiltrating CD8+ T cells. This evidence concerns the gene KDM4C and neoplasm.