In addition, it has been reported that the STING signal pathway and IFN-α are involved in T cell activation and function.29 30 Our results showed that STING, MAVS, TLR3 and IRF3 levels remained constant when KDM4C was depleted in A549 and Lewis tumor cells (online supplemental figure S6), suggesting that STING signal pathway and IFN-α are not involved in KDM4C-mediated biological processes in lung cancer. This evidence concerns the gene IRF3 and lung cancer.