CD8A and cancer: The chemokines CCL2, CCL3, CCl4, CCL5, CXCL9, CXCL10, and CXCL11 are known to be associated with T cell related tumor infiltration.37 CXCL9, CXCL10, and CXCL11 (ligands of CXCR3) are particularly critical because their expression is associated with prolonged disease-free survival in cancer patients.6 To explore the intricate mechanism of CD8+ T cell regulation by KDM4C inhibition, we performed RNA-seq and found that the cytokine–cytokine receptor signaling pathway was significantly enriched after SD70 treatment and that the expression of many chemokines was significantly upregulated.