Interestingly, it has recently been documented that the depletion of Ndrg1 suppressed the production of osteocalcin and enhanced cell proliferation, along with the suppression of p21 expression in osteosarcoma cells, suggesting the potential role of Ndrg1 in the cell differentiation of osteosarcoma cells [29]. This evidence concerns the gene NDRG1 and osteosarcoma.