Within this set of genes, there are the epigenetic regulators ARID1A and SMARCA2, which form part of the chromatin remodeling complex, SWI/SNF, and the DNA damage repair genes ATM and HERC2. Most of the genes mutated in Rosa26-RRAS2 CLL leukemias and human CLL leukemias are also found mutated in other hematological cancers of B and T cells (Fig. 3d). Here, HERC2 is linked to B-cell chronic lymphocytic leukemia.