A table with the list of genes identified in four or more human CLL patients shows that, in addition to ATM, other known tumors suppressors such as ARID1A, AKAP13, PRDM2, SPEN, SMARCA2 and TET2 are also mutated (Fig. 3D). The gene discussed is PRDM2; the disease is B-cell chronic lymphocytic leukemia.