The results of human RRAS2 mRNA expression in our cohort of samples (Fig. 5), in repository data (Fig. 1c and S1a), and the effect of RRAS2 overexpression in mouse B cells driving the development of CLL strongly suggest that overexpression of unmutated RRAS2 also drives the development of human CLL. The gene discussed is RRAS2; the disease is B-cell chronic lymphocytic leukemia.