The comparison of the transcriptome of six wild-type follicular B cell samples and seven independent leukemic samples using the Ingenuity Pathway Analysis (IPA) software revealed a strong signature of pathway alterations related to molecular mechanisms of cancer (Fig. S5b), thus confirming the malignant nature of the CD19 + CD5+ B cells expanding in Rosa26-RRAS2xmb1-Cre mice. This evidence concerns the gene CD5 and cancer.