A classification of leukemias by fold expression intervals showed that 82% of all samples overexpressed two-fold or more RRAS2 mRNA than B cells from healthy controls, although the distribution by sex was unequal: 13.6% of leukemias from male patients expressed lower than 2-fold levels compared to 25.4% for female patients (Fig. 5j). The gene discussed is RRAS2; the disease is leukemia.