The Asian Cancer Research Group (ACRG) performed targeted sequencing of 251 gastric tumors including a selection of collagens including COL11A1, COL12A1, COL21A1, COL22A1, COL4A1, COL5A1, COL5A3, COL6A3, and COL6A5 [35]. The gene discussed is COL22A1; the disease is gastric neoplasm.