Both indirect and direct hyperbilirubinemia are associated with hypopituitarism, andresolve with replacement of growth hormone and hydrocortisone.11 Cholestatic jaundice is never benign and should be evaluated, especially to excludebiliary atresia as surgical intervention prior to 2 months improves the outcome.12 It is imperative that these patients be closely followed by specialists in additionto their primary care pediatricians. This evidence concerns the gene GH1 and Hyperbilirubinemia.