It is reasonable to speculate that the presence of several polymorphisms of the ACE (I/D), ACE2 (rs2074192, rs1978124, rs2074809, rs2074666) and AGTR1 (rs5183, rs5185, rs5186) genes could explain both, the propensity to infection, the extension to different organs and the degree of the severity of the COVID-19 clinical presentations [13, 14]. The gene discussed is ACE; the disease is COVID-19.