COL3A1 and Ehlers-Danlos syndrome, vascular type: Vascular EDS (vEDS, MIM #130050), caused by mutations in the COL3A1 (MIM *120180) gene, is relatively the most severe subtype which could be lethal owing to vascular dissection or rupture, gastrointestinal perforation, or organ rupture (Byers, 1999).