Multivariate regression analysis revealed in model 1 that IL-6 and TLR2 genotypes (SNP; rs3804099) were independent risk factors for progression of liver disease from inactive carrier state to active hepatitis state (P = 0.03, OR = 2.5 and 95% CI: 1.4–6.68) and (P = 0.008, OR = 0.65 and 95% CI:0.08–1.13, respectively). The gene discussed is TLR2; the disease is liver disorder.