Meanwhile, viral load, IL-6 and TLR2 genotypes (SNP; rs3804099) were independent risk factors for progression of liver disease from active hepatitis state to liver cirrhosis with (P = 0.005, OR = 1.78, 95% CI: 1.12–4.54), (P < 0.001, OR = 2.68, 95% CI: 1.4–9.18) and (P < 0.001, OR = 0.5, 95% CI: 0.17–2.08), respectively, (Table 5). Here, TLR2 is linked to cirrhosis of liver.