RAC1 and epilepsy: A current study demonstrated that downregulated RAC1 decreased recurrent seizures in animal models of epilepsy, and found that RAC1-GTP was exclusively implicated in the mechanism of epilepsy(Li et al. 2016). However, these authors did not further explore the upstream mechanism in reduced RAC1 activity in epilepsy and the downstream pathway of RAC1 in epilepsy also remains to be studied.