These approaches and their impact in the field have been nicely reviewed [136] and have recently led to the identification of SET1B as a specificity factor for HIF-dependent gene induction in hypoxia [40], defined mitochondrial genes, essential for the viability of tumour cells in hypoxia [137], used in synthetic lethality for hypoxic tumours [138]and identified susceptibilities in hypoxic liver cancer [139,140]. The gene discussed is SETD1B; the disease is neoplasm.