Perhaps consistent with the arthritis literature in general (Kato, 2020; Ma and Xu, 2013; Ogata et al., 2019; Suhrbier, 2019), pronounced foot swelling in all comparisons (including MitoTEMPO, see below) was associated with upregulation of TNF, IFNG, and IL-6 USRs (Figure 4e, red box). Here, IFNG is linked to arthritic joint disease.