Female Cystatin C-/- mice display significantly lower clinical signs of experimental autoimmune encephalomyelitis (EAE) when compared with 6J mice (Hoghooghi et al., 2020); however, Cystatin C-/- mice were all Nnt+ (Figure 8, BioProject PRJNA662247; Supplementary file 7d). This evidence concerns the gene NNT and experimental autoimmune encephalomyelitis.