T cells with the investigated phenotype (i.e., Tphe+ cells), have increased frequency in the blood of several autoimmune conditions including rheumatoid arthritis and such T cells have been found to display autoreactivity in autoimmune hepatitis.[20, 29, 30] Thus, our findings represent a proof‐of‐concept for phenotype‐based isolation of disease‐specific CD4+ T cells in CeD that may be helpful in the identification of disease‐relevant CD4+ T cells in other autoimmune conditions. The gene discussed is CD4; the disease is cranioectodermal dysplasia.