HLA-C and autoimmune disease: Autoimmune diseases are complex disorders with the involvement of multiple susceptibility genes.[1] Across diseases, it is observed that human leuckocyte antigen (HLA) (major histocompability complex, MHC) genes have by far the biggest effect size.[2] The HLA association with disease is best explained by the preferential presentation of antigen by the disease‐associated allotypes, yet the disease‐driving antigens remain unknown for the majority of HLA‐associated disorders.