We recently reported that in treated CeD at baseline before gluten challenge a fraction of the gluten‐specific CD4+ T cells express CXCR5 and that the cells upon in vivo activation express other markers, such as CD161, CD147, and CD132—that are not typically associated with T‐cell help.[22] Thus, herein we have termed CD4+ T cells with this distinct phenotype T phenotypic (Tphe). Here, CD4 is linked to cranioectodermal dysplasia.