CD4 and cranioectodermal dysplasia: Similarly, we have previously demonstrated by mass cytometry that the frequency of Tphe+ cells among CD4+ gut T cells was 5% in untreated CeD patients, in contrast to 0.1% in healthy controls.[19] Taken together, the seven phenotypic markers clearly separate gluten‐HLA‐DQ2.5‐tetramer binding cells from most other CD4+ T cells in the inflamed gut tissue of CeD patients.