Conceivably, isolation of pathogenic CD4+ T cells and insights into their T‐cell receptor (TCR) repertoires may lead to the identification of disease‐driving self and/or foreign antigens, through TCR‐directed approaches with peptide‐MHC libraries and by computation.[3, 4, 5] By identification of pathogenic CD4+ T cells in autoimmune disease, novel targets for immunotherapy may be identified. Here, CD4 is linked to autoimmune disease.