As another example, AmB, the golden standard for antimycotic treatment for the most severe fungal infections,[49] exhibits part of its killing efficacy through ROS burst after binding with ergosterol.[50] However, high‐dose AmB treatment often leads to acute renal failure as a well‐documented serious complication.[51] Our findings suggest an alternative approach to tune down the usage of AmB by photoinactivation of catalase. Here, CAT is linked to acute kidney injury.