IL36RN and infectious otitis media: The cell–matrix adhesion network and Wnt signaling pathways crosstalk heavily during development.[37, 38] Interestingly, the Wnt signaling pathway was downregulated in Il1f9−/− colon tissues and tumors and upregulated in Il1f5−/− colon tissues and tumors from DSS‐ or AOM/DSS‐treated mice compared to the controls (Figure 5A,B and Figure S5A,B, Supporting Information).