We noted that the cytokine and chemokine signaling pathways were similarly downregulated in Il1f9−/− tumors (vs Il1f9+/+ tumors) and Il1f5−/− tumors (vs Il1f5+/+ tumors) obtained from the AOM/DSS colon cancer model (Figure S4A,B and Tables S4 and S5, Supporting Information). Here, IL36RN is linked to infectious otitis media.