Although the activation status of NF‐κB is comparable between the IL‐36γ KO or the IL‐36Ra KO tumors and the controls, the expression levels of cytokine and chemokines were similarly downregulated in Il1f9−/− and Il1f5−/− inflammatory colon tissues or colon tumors compared to the controls. Here, NFKB1 is linked to colonic neoplasm.