In the AOM/Vil‐Cre;Trp53fl/fl (VP) model, knockout of IL‐36γ significantly reduced tumor incidences and tumor numbers and sizes in colon, whereas knockout of IL‐36Ra led to increased lethality, tumor numbers, and sizes (Figure 2A–D and Table S1, Supporting Information). The gene discussed is IL36RN; the disease is neoplasm.