Elastase‐mediated cleavage at the N‐termini of IL‐36 cytokines is critical for the maturation and activation, which can be blocked by the z‐Ala‐Pro‐Ile (z‐API) peptide.[39, 40] Intraperitoneal injection of z‐API alleviated the symptoms of colitis in wild‐type mice but not in Il1f9−/− mice (Figure S6, Supporting Information), indicating that IL‐36γ is the major target of z‐API in the DSS colitis model. This evidence concerns the gene IL36G and colitis.