In contrast, the cell–matrix adhesion and Wnt signaling pathways were inhibited in the IL‐36γ KO colon tumors and potentiated in the IL‐36Ra KO colon tumors, respectively, indicating that IL‐36γ and IL‐36Ra reciprocally regulate cell‐matrix and Wnt signaling but not cytokine‐ and chemokine‐related immune signaling in the colon. The gene discussed is IL36G; the disease is colonic neoplasm.