In the AOM/Vil‐Cre;Trp53fl/fl (VP) model, knockout of IL‐36γ significantly reduced tumor incidences and tumor numbers and sizes in colon, whereas knockout of IL‐36Ra led to increased lethality, tumor numbers, and sizes (Figure 2A–D and Table S1, Supporting Information). This evidence concerns the gene VIL1 and infectious otitis media.