Results from qRT‐PCR and immunoblot analysis confirmed that deficiency in IL‐36γ and IL‐36Ra impaired and promoted the expression of downstream genes involved in Wnt signaling in the tumors from AOM/VP and ApcMin/+ colon cancer models, respectively (Figure 5C,D and Figure S5C, Supporting Information). The gene discussed is IL36RN; the disease is malignant colon neoplasm.