Similarly, despite the ability of TLR2 to activate phagocytic activation of macrophages due to L. donovani infection, silencing either TLR2 or TLR3 impairs the secretion of NO and TNF‐α post‐infection of IFN‐γ‐primed macrophages with L. donovani promastigotes.89 This evidence concerns the gene IFNG and infection.