Probing cell line and clinical transcriptomes revealed the existence of multiple clusters of cancers; a relatively small subpopulation of cancer types in which YAP/TAZ are silenced, constituting haematological malignancies and small cell neuroendocrine cancers, and the majority of those in which YAP/TAZ are actively expressed, primarily consisting of solid, non-neuroendocrine tumours [214]. Here, YAP1 is linked to neuroendocrine neoplasm.