WWTR1 and neoplasm: Additionally, Hippo pathway dysregulation has been shown to result in tumorigenesis similar to that seen in cancer types involving YAP/TAZ fusion proteins, with both expression of constitutively active YAP or KO of LATS1/2 in a subpopulation of neuronal precursor cells in mice resulting in the formation of ependymoma-like tumours and up-regulation of YAP/TAZ target genes [109].