Both GPCRs and G proteins are frequently mutated across a vast variety of cancer types, with GPCR, Gαq/11 and Gαs mutations present in ∼20, 4 and 6% of all human cancers [174], while recent work has suggested that G protein disruption may be even more common than previously observed when mutually exclusive mutations across G protein families are considered [175]. The gene discussed is GNAQ; the disease is cancer.