However, as a subset of cancers exist in which YAP/TAZ act as putative tumour suppressors [205,210,214], there is a possibility that these cancers may be vulnerable to inhibition of the core Hippo kinase cascade; this approach would however require validation and caution, as MST1/2 classically act as tumour suppressors [230–232]. This evidence concerns the gene YAP1 and cancer.