Many of the rare cancer types that exhibit frequent YAP/TAZ fusions are associated with a generally low mutational burden, with supratentorial ependymomas characterised by fusion proteins in just two oncogenes (YAP and RELA) [101,103], while in EHE, <20% of patients exhibit a canonical oncogenic alteration beyond YAP/TAZ fusion [112]. The gene discussed is YAP1; the disease is cancer.