The regularity of YAP fusion proteins in ependymomas and meningiomas, tumour types associated with neurofibromatosis 2, alongside preliminary findings to suggest exclusivity with NF2 mutation [101,106], is further evidence that Hippo pathway dysregulation is a common driver of oncogenesis in these rare cancer types of the nervous system. The gene discussed is NF2; the disease is NF2-related schwannomatosis.