YAP1 and cancer: However, recent in vitro and in vivo experiments have shown that YAP further mediates the oncogenic potential of RhoA, driving the expression of downstream transcriptional programs that induce restructuring of the cytoskeleton and extracellular matrix, enhancing cancer cell invasion [190,191], while LPA-mediated RhoA activation and subsequent dephosphorylation of YAP induce migration in ovarian cancer cells [192].