From a functional perspective, the kinase module generally acts in a tumour suppressive manner, phosphorylating and inactivating the transcriptional module members, YAP (Yorkie or Yki) and its paralogue TAZ (encoded for by YAP1 and WWTR1 genes respectively), which were identified as oncogenes shortly after their initial discovery [30,31]. This evidence concerns the gene YAP1 and neoplasm.