Loss of heterozygosity in chromosome 11q22-q23, the region containing YAP1, has historically been observed in breast cancer [206], while YAP knockout or KD in a variety of breast cancer cell lines yields a reduction in tumorigenic potential, as determined by capacity for anchorage-independent growth, migration, and ability to form xenografts in mice [207,208]. The gene discussed is YAP1; the disease is breast carcinoma.