YAP1 and Familial prostate cancer: In liver and prostate cancer mice cell models, hyperactive YAP recruits macrophages [253] and myeloid-derived suppressor cells (MDSCs) [254] respectively, in both cases acting with TEAD to initiate the expression of immunosuppressive cytokines such as CXCL5, CXCL1/2 and CCL2, repressing the immune response.