In the context of human cancers, YAP/TAZ in some instances act downstream of MEKK3 (or MAP3K3) to maintain stemness in pancreatic cancer cells [144], while collation of single cell RNA-seq (scRNA-seq) datasets from patients with glioblastoma (GBM) revealed that YAP and TAZ drive a regulatory network associated with the GBM stem cell state [145]. This evidence concerns the gene MAP3K3 and glioblastoma.