NUF2 and posterior cortical atrophy: CDCA1 was initially identified as a component of the kinetochore complex, which is evolutionarily conserved and important for the stability of kinetochore and microtubule.[15] Depletion of CDCA1 has been reported to lead to a deficiency of kinetochore microtubule attachment and activation of the spindle checkpoint, ultimately leading to the death of mitotic cell.[16] In a study by Zhao et al,[17] CDCA1 was overexpressed in PCa cell lines, and the expression level of CDCA1 in human PCa tissues was significantly higher than that in adjacent normal tissues.