CDCA5 ensures precise cell chromosome separation during meiosis and mitosis and maintains sister chromatid cohesion by stabilizing the cohesive complex; it also plays an important role in DNA repair.[24] Moreover, CDCA5 regulates the activity of cell cycle-related proteins and transcription factors, thereby promoting proliferation and participating in apoptosis in cancer cells.[25] In PCa, Ji et al[26] elucidated that CDCA5 functions through the ERK signaling pathway to promote tumor progression. The gene discussed is CDCA5; the disease is cancer.