CDCA8 and cancer: Studies have revealed that CDCA8 is upregulated in colorectal cancers, and that deficiency of CDCA8 induces apoptosis of cancer cells and suppresses growth.[28] CDCA8 may act as a promoter of lymph node metastasis in PCa and hopefully become a new diagnostic and therapeutic factor for PCa by bioinformatics analysis,[29] but validation is lacking in vivo and in vitro.