CDCA3 is a “trigger” for mitotic entry and has been reported to mediate cell cycle progression.[21] CDCA3 functions as a part of the S phase kinase-associated protein 1/Cullin 1/F-box (SCF) E3 ubiquitin ligase complex to mediate the destruction of the mitosis inhibitory kinase wee1, thus imparting an important effect on the cell cycle.[22] Chen et al[23] suggested that HoxB3 promotes PCa progression by transactivating CDCA3 expression and preventing G1 phase arrest. This evidence concerns the gene CUL1 and posterior cortical atrophy.