APOE and lipoprotein glomerulopathy: LPG diagnosis depends on clinical, pathological, and laboratory surveys.[22] The Angiotensin-converting enzyme inhibitors, fenofibrate, and apheresis (e.g., immunoadsorption using protein A columns) have been demonstrated to improve the outcome of patients with LPG.[21] But there is insufficient data to highlight the roles of different heterozygous forms of APOE in diagnosis, treatment, prognosis, and pregnancy counseling.