DNMT3A and myeloproliferative disorder: By sequencing of 42 genes which are related with acute myeloid leukemia/myeloproliferative neoplasms/myelodysplastic syndrome including ASXL1, CALR, CBL, CEBPA, CSF3R, CUX1, DNMT3A, EED, ETV6, EZH2, FLT3, GATA2, GNAS, HRAS, IDH1, IDH2, IKZF1, JAK2, JAK3, KDM6A, KIT, KRAS, MPL, NF1, NOTCH1, NPM1, NRAS, PTPN11, RUNX1, SETBP1, SF3B1, SH2B3, SRSF2, STAG2, SUZ12, TET2, TP53, U2AF1, WT1, BCOR, PHF6, and ZRSR2, the mutations of c-Kit (p.D816V, 32.35%), DNMT3A (p.R882H, 45.15%) were detected (Fig. 4).