In this study, we found that simvastatin treatment remarkably reduces the transcription levels of TGF‐β1, TGF‐β2 and TGF‐β3 by 2.04‐fold, 3.33‐fold and 2.78‐fold in leiomyoma stem cells compared to untreated control (Figure 5A,C,D). This evidence concerns the gene TGFB2 and leiomyoma.