Somatic stem cells can be reprogrammed into pluripotent stem cells with self‐renewal, transcriptional function and tumorigenesis potential.3, 4 In agreement with previous studies, we observed higher Nanog, Oct4 and Sox2 levels, confirming the undifferentiated status of isolated leiomyoma stem cells compared to the mature and total cell populations, and their expression was significantly suppressed by simvastatin. The gene discussed is POU5F1; the disease is leiomyoma.