SMAD7 and leiomyoma: Simvastatin significantly decreased the mRNA levels of NF‐κB by 2.00‐fold and the protein levels of phosphorylation of NF‐κBp65 by 1.54‐fold in leiomyoma stem cells compared to control (Figure 6H,I), suggesting the reduction of SMAD7 activated inflammation may be via NF‐κB dependent pathway.36