LAMB2 and leiomyoma: Fibrosis is one of the hallmarks of leiomyomas, where dysregulated ECM plays a crucial role.30, 31 ECM such as collagen, fibronectin, laminins and proteoglycan are overexpressed in ULs, which induces mechanotransduction by integrin activation and increases tissue stiffness by altering bidirectional signalling.31