Several growth factors, inflammatory cytokines and matrix metalloproteinases play a vital role in ECM accumulation and remodelling in ULs.32, 40 Overproduction of TGF‐β3 is extensively recognized as a key element in tissue fibrosis, involved in the accumulation of collagen 1, fibronectin, laminin and proteoglycan besides induction of leiomyoma cells proliferation and ULs growth.40, 41 In this study, we found that simvastatin decreases TGF‐β1, 2 and 3 expressions in leiomyoma stem cells. This evidence concerns the gene LAMB2 and leiomyoma.