While SP cells of the pancreatic cancer cell lines PANC-1 and Capan-2 were more responsive than NSPs (bulk cells without the SP fraction) to TGF-β1 switching their phenotypic traits for epithelial to mesenchymal and back upon reversal of TGF-β1 treatment [13]. This evidence concerns the gene TGFB1 and familial pancreatic carcinoma.