TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: In conclusion, the organoids derived from metastatic tRCC with PRCC-TFE3 fusion that we presented here fulfilled all the criteria of a reliable in vitro cancer model, recapitulating the dominating features of the most common fusion subtype of tRCC, from histological architecture to genetic traits.