HPA features the transformation of liver sinusoidal endothelial cells (LSECs) into the vascular type and contributes to the progression of cirrhosis and portal hypertension [38], VEGFA with a secreted growth factor containing signal peptides can specifically promote the mitosis of vascular endothelial cells and induce the occurrence of angiogenesis [39,40], which could regulate angiogenesis both in physiological and pathological conditions [41]. The gene discussed is VEGFA; the disease is portal hypertension.