HGS and Familial prostate cancer: Surface markers of prostasomes, albeit produced from a prostate cancer cell line (PC-3), are enriched with several multivesicular bodies and EV markers including hepatocyte growth factor-regulated tyrosine kinase substrate (HGS), lysosomal-associated membrane protein 1 and 2 (LAMP1 and LAMP2), and tumour susceptibility gene 101 (TSG101) (Llorente et al. 2004, Llorente et al. 2007).