PARP1 and neoplasm: Tumor-associated macrophages and microglia have been shown to play an important role in creating an immunosuppressive tumor environment that protects tumor cells from recognition and destruction by the immune system.95 While one might speculate that PARP inhibition would further suppress microglial activity, thus protecting tumor cells, a recent abstract described the opposite effect.96 This illustrates the importance of assessing the neuroinflammatory effects of PARP inhibition in microenvironments that recapitulate the clinical scenario.