Between baseline and onset of hepatitis, there were significant differences in the median ALT:ULN ratio (4.9 versus 1.0, P < 0.0001), AST:ULN ratio (3.1 versus 0.8, P < 0.0001), ALP:ULN ratio (1.2 versus 0.7, P < 0.0001) and bilirubin:ULN ratio (0.8 versus 0.6, P = 0.005). This evidence concerns the gene GPT and Hepatitis.