CSF2 and neoplasm: Pexa-Vec (JX-594, pexastimogene devacirepvec) is a Wyeth strain oncolytic vaccinia virus engineered with viral thymidine kinase gene disruption and human granulocyte-macrophage colony-stimulating factor (hGM-CSF) transgene expression to favor replication selectivity for tumor cells and promote immune-activation.6