SIRT7 and persistent truncus arteriosus: In cardiac-specific Sirt7-depletion mice, hypertrophic response was significantly augmented, as evidenced by increased heart weight/tibial length, larger CM cross-sectional area, and deteriorated heart function compared to WT mice receiving TAC operation, and further mechanism investigation indicated that The anti-hypertrophic roles of Sirt7 may be attributed to the deacetylation of GATA4 (56).