SOD2 and cardiac hypertrophy: Treatment with diazoxide in ISO-induced cardiac hypertrophy mice to open mitoKATP significantly improved MnSOD activity and decreased H2O2 production, and it went the opposite when treated with 5-hydroxydecanoate or glibenclamide (mitoKATP blockers), indicating that mitoKATP opening seems promising to block oxidative stress and ameliorate cardiac hypertrophy (84).