Moreover, in Atg7- or Parkin-deficient HFD mice, cardiac hypertrophy, diastolic dysfunction and lipid accumulation deteriorated and mitophagy was dramatically impaired, suggesting that mitophagy may serve as an adaptive mechanism to protect against diabetic cardiomyopathy in an Atg7- or Parkin-dependent manner. The gene discussed is ATG7; the disease is diabetic cardiomyopathy.