AGT and cardiac hypertrophy: MICU1 was depressed in hypertrophic hearts, and in vivo and in vitro experimental data suggested that MICU1 ablation aggravated cardiac hypertrophy induced by Ang-II infusion, as evidenced by the worsened cardiac function, increased hypertrophic biomarkers, and cardiac histological alterations; in contrast, cardiac MICU1 supplementation ameliorated CM enlargement and blunted cardiac dysfunction (38).