Moreover, in Atg7- or Parkin-deficient HFD mice, cardiac hypertrophy, diastolic dysfunction and lipid accumulation deteriorated and mitophagy was dramatically impaired, suggesting that mitophagy may serve as an adaptive mechanism to protect against diabetic cardiomyopathy in an Atg7- or Parkin-dependent manner. Here, PRKN is linked to diabetic cardiomyopathy.