AKT1 and cancer: Figure 3E shows that some variant genes were related to complex cancer pathways. These genes were mainly involved in the JAK/STAT, PT3K/AKT, WNT, and MAPK/ERK pathways, and could influence each other (e.g., in terms of activation, inhibition, and phosphorylation), which could lead to cell evading apoptosis, cell proliferation, sustained angiogenesis, etc. and in turn affect the occurrence and development of cancers.