IL6 and systemic lupus erythematosus: In addition to type I IFNs, Hjorton et al. (75) demonstrated that RNA-containing immune complexes (RNA-ICs), found in patients with SLE, have the capacity to induce type III IFN (e.g., IFNλ1–3) production, which increased in the presence of GM-CSF, IL3, IL6 and IFNα2b, indicating that both type I and type III IFNs have a contributing role in SLE.