21 leukocyte subsets found in renal biopsies, IFN signature found in most leukocytes, correlated with that in peripheral blood, upregulated expression of chemokine receptors CXCR4 and CX3CR1 in renal tissues of patients with LN, correlation between gene expression signatures of leukocytes from urine and kidneys. This evidence concerns the gene CXCR4 and lobular neoplasia.