REN and hypertensive disorder: The renin-angiotensin-aldosterone system (RAAS) is a well-known regulator of blood pressure and renal fibrosis that has been widely targeted by different antihypertensive agents including renin inhibitors, aldosterone inhibitors, angiotensin converting enzyme inhibitors (ACEi), and angiotensin receptor blockers (ARBs) to control hypertension and the progression of hypertensive nephrosclerosis (HNS) (8).