Among these patients with anti-PM/Scl antibodies, the occurrence of skin rashes in the Ro-52 antibody-positive group were significantly higher than the group without Ro-52 (p = 0.024), but Raynaud's phenomenon, arthritis, fever, mechanic's hands, and muscular weakness in the Ro-52 group were not significantly different from the group without Ro-52 (p > 0.05). This evidence concerns the gene TRIM21 and exanthem.