LPL and hypertriglyceridemia: In the case of lipoprotein lipase (LPL) deficiency (LPLD), an orphan disease associated with chylomicronemia, severe hypertriglyceridemia, metabolic complications, the use of AAV vectors encoding a GOF gene variant of LPL (S447X), showed efficacy in LPLD patients avoiding safety concerns related to immune response to AAV-capsid proteins (49).