In 2016, Cui et al. constructed an ovariectomy-induced osteoporosis rat model and found that the levels of RIP1, RIP3, and MLKL proteins were significantly elevated in rat femurs and a large number of necrotic osteocytes with positive TUNEL staining but negative caspase-3 staining were seen. This evidence concerns the gene RIPK3 and osteoporosis.