In breast cancer (Nadanaka et al., 2021), multiple myeloma (Purushothaman and Sanderson, 2020) and pancreatic cancer (Chen et al., 2020), greater SDC-1 shedding was similarly found to associate with increased metastasis, indicating that shed SDC-1 likely serves as a major facilitator for malignant cellular invasion. The gene discussed is SDC1; the disease is AL amyloidosis.