The nuclear translocation of SDC-1, however, was also reported to facilitate elimination of mesenchymal and invasive characteristics among human B6FS fibrosarcoma cells, with loss of nuclear SDC-1 related to cell elongation and E- to N-cadherin switching during the TGF-β1-induced EMT in human A549 lung cancer cells (Kumar-Singh et al., 2021). Here, SDC1 is linked to fibrosarcoma.