Notably, reduction in miR-494 levels results in enhanced SDC-1 shedding and angiogenesis in medulloblastoma cells, while miR-302a and miR-515-5p inhibit ovarian and bladder cancer cell growth correspondingly via the targeting of SDC-1 (Asuthkar et al., 2014; Guo et al., 2015; Cao et al., 2021). This evidence concerns the gene SDC1 and urinary bladder carcinoma.