HPSE and familial pancreatic carcinoma: As noted above, commonly used chemotherapy and radiation regimens promote heparanase upregulation and increase SDC-1 shedding in malignancies such as myeloma (Bandari et al., 2018), pancreatic cancer (Ramani and Sanderson, 2014) and medulloblastoma (Asuthkar et al., 2014).