SDC1 and familial pancreatic carcinoma: Considering that shed SDC-1 promotes the EMT, high levels of shed SDC-1 were found to upregulate expression of EMT-TFs including ZEB1, Snail1 and Snail2 in breast and pancreatic cancer models to induce expression of the stemness factors SOX2, BMI1, and OCT4, thus facilitating chemoresistance (Pradella et al., 2017).