Emerging studies have shown that baicalein is a selective inhibitor of ALOX12/15, which in turn strongly downregulates prostaglandin-endoperoxide synthase 2 (PTGS2) and upregulates GPX4, and significantly suppresses ferroptosis to exhibit a neuroprotective role in post-traumatic epileptic seizures (Li Q. et al., 2019). The gene discussed is PTGS2; the disease is Seizure.