FOCAD is essential for focal adhesion kinase (FAK) activity, which further enhances the sensitivity of NSCLC cells to cysteine deprivation-induced ferroptosis via promoting the tricarboxylic acid (TCA) cycle and the activity of Complex I in the mitochondrial electron transport chain (ETC) (Liu P. et al., 2020). The gene discussed is FOCAD; the disease is non-small cell lung carcinoma.