Mechanistically, interferon gamma (IFNγ) released from CD8+ T cells can impair cystine uptake by cancer cells upon downregulating the expression of SLC3A2 and SLC7A11 (two subunits of the cystine-glutamate antiporter system xc-) and consequently promote lipid peroxidation and ferroptosis in ovarian cancer, melanoma and fibrosarcoma (Tsoi et al., 2018; Wang W. et al., 2019; Lang et al., 2019). This evidence concerns the gene CD8A and melanoma.