The Hippo pathway is usually believed to control cell number, organ size, tissue development and tumor growth, which negatively regulates the activity of several transcription factors, including transcription coactivators (e.g., yes-related protein 1 (YAP1) and WW domain containing transcription regulator 1 (WWTR1, also known as TAZ). The gene discussed is WWTR1; the disease is neoplasm.