The p62-Keap1-NRF2 pathway prevents ferroptosis and reduced GSH promote ferroptosis in liver cancer cells; Metallothionein-1 (MT-1), which inhibits lipid peroxidation, are associated with drug resistance and reduced overall survival; Ferroptosis inhibits liver tumorgenesis and is suppressed in liver cancer; XCT expression is higher, inversely related to the patient’s overall survival rate and disease-free survival rate. This evidence concerns the gene KEAP1 and liver cancer.