GPX4 and cancer: Furthermore, increased expression of SLC7A11, GPX4 or their upstream regulatory gene NRF2 not only promotes ferroptosis resistance, but is also correlated with a poorer prognosis and lower survival rate in many types of cancers, such as liver, lung and ovarian cancers (Fan et al., 2017; Daher et al., 2019; Lim et al., 2019).