NFE2L2 and cancer: The inhibition of NRF2 by trigonelline enhances the anticancer activity of classical ferroptosis inducers, such as erastin, sorafenib and RSL3, and sensitizes chemoresistant cancer cells to ferroptosis both in vitro and in vivo models of HCC and HNC (Sun et al., 2016a; Shin et al., 2018).