In contrast, the activation of transcription factors involved in the Hippo pathway promotes ferroptosis in human renal cell carcinoma or ovarian cancer cells by regulating the expression of ferroptosis modulators (e.g., YAP-mediated ACSL4 and TFRC expression, TAZ-mediated epithelial membrane protein 1 (EMP1) and angiopoietin-like 4 (ANGPTL4) expression) to increase iron accumulation and lipid peroxidation (Yang et al., 2019; Yang Y. H. et al., 2020) (Figure 2). This evidence concerns the gene ANGPTL4 and hereditary clear cell renal cell carcinoma.