Both AF and TYP trigger ferroptosis in an autophagy-dependent manner via AMPK signaling, contributing to ferritin degradation, ROS accumulation and ultimately ferroptotic cell death in acute myeloid leukemia (AML) and glioma (Zhu et al., 2019; Chen Y. et al., 2020). The gene discussed is DUSP4; the disease is acute myeloid leukemia.