Yet, GLY, a high mobility group protein B1 (HMGB1) inhibitor, has been shown to reduce the degree of ferroptosis of hepatocytes during acute liver failure (ALF) via activating NRF2/HO-1/HMGB1 pathway to antagonize oxidative stress (Wang Y. et al., 2019). The gene discussed is HMGB1; the disease is acute liver failure.