In the CGGA cohort, compared with LGG, the expression of PUS1, PUS7, RPUSD1, RPUSD3 and DKC1 were distinctly up-regulated in GBM; meanwhile, the expression of TRUB1 and PUS7L were significantly down-regulated in GBM (Figures 2A,B). Here, RPUSD3 is linked to glioblastoma.