Furthermore, activating the HIF-1α pathway with hypoxia-mimicking agents such as deferoxamine and dimethyloxalylglycine can decrease the bone loss associated with ovariectomy-induced osteoporosis (Zhao et al., 2012; Peng et al., 2014), prevent ultra-high-molecular-weight polyethylene-induced osteolysis (Kang et al., 2016), and facilitate the healing of osteoporotic bone defects (Jia et al., 2016). The gene discussed is HIF1A; the disease is osteoporosis.