B.1.351 is mainly characterized by the triple mutations in the RBD of the S protein and associated with reduced nAb titers (9-fold) and global efficacy against infection (10.4-20.4%) and impaired efficacy (21.9%) to prevent mild to moderate COVID-19 (Dejnirattisai et al., 2021; Madhi et al., 2021; Planas et al., 2021; Zhou et al., 2021). This evidence concerns the gene PROS1 and COVID-19.