In the multivariate hazards model, maxim tumor size of ≥5 cm, presence of macro-vascular invasion and PD-L1 ≥3.0 remained significantly associated with increased risk of recurrence, while serum AFP ≥200 ng/ml (HR 1.42, 95%CI: 0.91–2.20) was not an independent risk factor. This evidence concerns the gene AFP and neoplasm.