Both maxim tumor size of ≥5 cm (HR 2.13, 95%CI: 1.23–3.69) and macro-vascular invasion (HR 2.08, 95%CI: 1.29–3.37) were related with an approximately two-fold risk of recurrence, while a 1.88-fold risk (95%CI: 1.18–2.99) was observed in patients with overexpression of PD-L1 (Table 3). This evidence concerns the gene CD274 and neoplasm.