In addition, we overexpressed KISS1 and KISS1R in 5-8F cells, and found that the cells overexpressed KISS1 and the cells co-overexpressed KISS1-KISS1R showed a low proliferative ability, but not the cells overexpressed KISS1R. This suggests the important role of KISS1 in nasopharyngeal carcinoma, but whether the role of KISS1R in nasopharyngeal carcinoma is remain to be further explored. The gene discussed is KISS1; the disease is nasopharyngeal carcinoma.